Pre-treatment blood test could guide lung cancer therapy

A team of researchers led by Vanderbilt-Ingram Cancer Center, University of Colorado, Aurora, have discovered that certain types of protein present in the blood could predict the benefits of targeted cancer therapy in non-small lung cancer patients. “There’s a real clinical need to identify which patients will benefit from targeted therapies. If our findings are confirmed, we will be able to use a simple and inexpensive blood test to select the most beneficial therapy for each patient,” said Dr. David Carbone, professor at Cancer Research, Vanderbilt-Ingram. Targeted therapy with the drugs EGF receptor tyrosine kinase inhibitors (TKIs) can lead to a 30 to 40% survival benefit for some non-small lung cancer patients. Previously, it was unclear which patients would benefit from targeted therapy over chemotherapy. The researchers analyzed pre-treatment blood samples from patients and found that for patients with a "signature" of eight proteins, targeted therapy led to prolonged survival.

Researchers at the University of Florida have found that talcum powder stunts cancer growth by cutting blood flow to metastatic lung tumors. According to the research report, talc stimulates healthy cells to produce a hormone called endostatin, which enhances the treatment of metastatic lung cancer. “Talc is able to prevent the formation of blood vessels, thereby killing the tumor and choking off its growth,” said Veena Antony, professor of pulmonary medicine. The report, published in the European Respiratory Journal, also states that the effects of medical thoracoscopy with talc pleurodesis are immediate. The doctors observed that the patients who underwent medical thoracoscopy with talcum powder lived up to 18 months longer than expected.

Scientists at the University of California, Irvine, found that a drug used to treat cancer could enhance long-term memory and strengthen neural connections in the brain. According to the study, histone deacetylase (HDAC) inhibitors, currently used in the clinical treatment of cancerous tumors, could boost memory in humans and be therapeutic for Huntington’s disease, Alzheimer’s and Rubenstein-Taybi syndrome.

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i reckon there should be more information on lung cancer than there is now

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