Brain region offsets stroke damage

Findings published by Jacinta O'Shea and colleagues at the University of Oxford in the journal Neuron, show that the dorsal premotor cortex (PMd) in the brain offsets the damage caused to the brain during a stroke. Researchers used magnetic pulses for disrupting the function in the left PMd of human volunteers, simultaneously setting them to a button-pushing task. Results from an MRI scan showed that in the case of a disruption in the left PMd, the right PMd and other areas involved in premotor functions restored brain activity.

Allison Brashear professor of neurology at Wake Forest University Baptist Medical Center, at the annual meeting of the American Academy of Neurology claimed that Botox treatment decreases spasticity-related pain after a stroke. A 12-month study of botulinum toxin type A (BoNTA) evaluating the efficacy and safety of repeated BoNTA treatments, involved 279 patients, who were injected with BoNTA at the elbow, wrist and fingers or thumbs flexor of the affected limb to wedge overactive nerve impulses that trigger excessive muscle contraction. “Having data to support a safe and effective profile for long-term treatment with BoNTA is significant for patients and caregivers,” said Brashear.

A study by Pierre Amarenco, MD, of Denis Diderot University in Paris, which is scheduled to be presented in the 59th Annual Meeting of the American Academy of Neurology in Boston, reported that statins reduced the risk of stroke and heart attack. Study involved 4,731 people within six months of having a stroke or transient ischemic attack and without a history of heart disease. Half of the participants received the cholesterol-lowering drug atorvastatin and half received a placebo. Inference showed that the average decrease in LDL cholesterol after one month on atorvastatin was 53%. In any case, a fat-free diet is better than cholesterol-lowering drug.

 

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