Antidepressant medication might increase risk of Parkinson’s disease

The 59th Annual meeting of American Academy of Neurology has reportedly presented a study emphasizing the consumption of anti-depressants and the resulting incidence of Parkinson's disease (PD). The Harvard School of Public Health has apparently noted that Parkinson's disease diagnosed in people who were taking anti-depressants was nearly twice as in those who were not taking anti-depressants. Previous research shows that antidepressants can cause depletion of dopamine, thereby making the victims of depression more vulnerable to PD, and therefore few studies suggest the use of dopaminergic antidepressant.

Study published in the Archives on Internal Medicine claims that depression could lead to type 2 diabetes. Study evaluating nearly 5,000 adults aged 65 or older revealed that those who got the blues were more likely to develop diabetes than those without depressive symptoms. However, the study neglects the factors leading to depression, further remaining silent on the onset of type 2 diabetes. Clinical trials have not until date associated clear link between diabetes and depression, except the inference that elevated levels of the stress hormone cortisol,  increases blood glucose levels and causes more fat to collect around the abdominal area.

Findings in the recent issue of ‘Preventive Medicine’ by researchers at the University Of Minnesota School Of Public Health reveal that there is no link between self-weighing and depression in women. Study examined 4,650 women between the ages of 40 and 65 from November 2003 to February 2005. Following the adjustment in BMI levels, the association between self-weighing and depression was inferred to be insignificant. Frequent self-weighing was independently associated with both the absence of depressive symptoms and lower BMI levels.

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Comments

[Ian]

Antidepressants do not increase the risk of developing Parkinson's Disease (PD) as the researchers in the study quoted made very clear -

"This should not be interpreted as evidence that antidepressants cause Parkinson's disease," said Miguel Hernan, MD, DrPH, of Harvard School of Public Health in Boston. "The relationship is only apparent in the year before the onset of the disease, which suggests that depression is an early symptom of the disease."

and

"It's very important not to say that people taking antidepressants have a higher risk of developing Parkinson's disease," study co-author Dr. Alvaro Alonso added.

The onset of depression, and the subsequent use of antidepressants, may be a predictor for PD, but there is no evidence that antidepressants themselves cause PD.

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Clinical trials have not until date associated clear link between diabetes and depression, except the inference that elevated levels of the stress hormone cortisol, increases blood glucose levels and causes more fat to collect around the abdominal area.

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